Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
Identifieur interne : 001955 ( Main/Exploration ); précédent : 001954; suivant : 001956Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.
Auteurs : Meng Wu [République populaire de Chine] ; Ziwen Wang ; Chuisong Meng ; Kailiang Wang ; Yanna Hu ; Lizhong Wang ; Qingmin WangSource :
- PloS one [ 1932-6203 ] ; 2013.
Descripteurs français
- KwdFr :
- Acide vanillique (), Acide vanillique (pharmacologie), Acides caféiques (), Acides caféiques (pharmacologie), Acides coumariques (), Acides coumariques (pharmacologie), Acrylates (), Acrylates (pharmacologie), Antiviraux (), Antiviraux (pharmacologie), Cinnamates (), Cinnamates (pharmacologie), Découverte de médicament, Feuilles de plante (virologie), Interactions hôte-pathogène (), Modèles chimiques, Relation structure-activité, Ribavirine (), Ribavirine (pharmacologie), Structure moléculaire, Tabac (virologie), Virus de la mosaïque du tabac (), Virus de la mosaïque du tabac (physiologie).
- MESH :
- pharmacologie : Acide vanillique, Acides caféiques, Acides coumariques, Acrylates, Antiviraux, Cinnamates, Ribavirine.
- physiologie : Virus de la mosaïque du tabac.
- virologie : Feuilles de plante, Tabac.
- Acide vanillique, Acides caféiques, Acides coumariques, Acrylates, Antiviraux, Cinnamates, Découverte de médicament, Interactions hôte-pathogène, Modèles chimiques, Relation structure-activité, Ribavirine, Structure moléculaire, Virus de la mosaïque du tabac.
English descriptors
- KwdEn :
- Acrylates (chemistry), Acrylates (pharmacology), Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Caffeic Acids (chemistry), Caffeic Acids (pharmacology), Cinnamates (chemistry), Cinnamates (pharmacology), Coumaric Acids (chemistry), Coumaric Acids (pharmacology), Drug Discovery, Host-Pathogen Interactions (drug effects), Models, Chemical, Molecular Structure, Plant Leaves (virology), Ribavirin (chemistry), Ribavirin (pharmacology), Structure-Activity Relationship, Tobacco (virology), Tobacco Mosaic Virus (drug effects), Tobacco Mosaic Virus (physiology), Vanillic Acid (chemistry), Vanillic Acid (pharmacology).
- MESH :
- chemical , chemistry : Acrylates, Antiviral Agents, Caffeic Acids, Cinnamates, Coumaric Acids, Ribavirin, Vanillic Acid.
- chemical , pharmacology : Acrylates, Antiviral Agents, Caffeic Acids, Cinnamates, Coumaric Acids, Ribavirin, Vanillic Acid.
- drug effects : Host-Pathogen Interactions, Tobacco Mosaic Virus.
- physiology : Tobacco Mosaic Virus.
- virology : Plant Leaves, Tobacco.
- Drug Discovery, Models, Chemical, Molecular Structure, Structure-Activity Relationship.
Abstract
A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.
DOI: 10.1371/journal.pone.0056475
PubMed: 23418574
Affiliations:
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Le document en format XML
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uniqKey="Meng C" first="Chuisong" last="Meng">Chuisong Meng</name></author><author><name sortKey="Wang, Kailiang" sort="Wang, Kailiang" uniqKey="Wang K" first="Kailiang" last="Wang">Kailiang Wang</name></author><author><name sortKey="Hu, Yanna" sort="Hu, Yanna" uniqKey="Hu Y" first="Yanna" last="Hu">Yanna Hu</name></author><author><name sortKey="Wang, Lizhong" sort="Wang, Lizhong" uniqKey="Wang L" first="Lizhong" last="Wang">Lizhong Wang</name></author><author><name sortKey="Wang, Qingmin" sort="Wang, Qingmin" uniqKey="Wang Q" first="Qingmin" last="Wang">Qingmin Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23418574</idno><idno type="pmid">23418574</idno><idno type="doi">10.1371/journal.pone.0056475</idno><idno type="wicri:Area/PubMed/Corpus">001251</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001251</idno><idno 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Elemento-Organic Chemistry, Nankai University, Tianjin, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Ziwen" sort="Wang, Ziwen" uniqKey="Wang Z" first="Ziwen" last="Wang">Ziwen Wang</name></author><author><name sortKey="Meng, Chuisong" sort="Meng, Chuisong" uniqKey="Meng C" first="Chuisong" last="Meng">Chuisong Meng</name></author><author><name sortKey="Wang, Kailiang" sort="Wang, Kailiang" uniqKey="Wang K" first="Kailiang" last="Wang">Kailiang Wang</name></author><author><name sortKey="Hu, Yanna" sort="Hu, Yanna" uniqKey="Hu Y" first="Yanna" last="Hu">Yanna Hu</name></author><author><name sortKey="Wang, Lizhong" sort="Wang, Lizhong" uniqKey="Wang L" first="Lizhong" last="Wang">Lizhong Wang</name></author><author><name sortKey="Wang, Qingmin" sort="Wang, Qingmin" uniqKey="Wang Q" first="Qingmin" last="Wang">Qingmin Wang</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylates (chemistry)</term><term>Acrylates (pharmacology)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Caffeic Acids (chemistry)</term><term>Caffeic Acids (pharmacology)</term><term>Cinnamates (chemistry)</term><term>Cinnamates (pharmacology)</term><term>Coumaric Acids (chemistry)</term><term>Coumaric Acids (pharmacology)</term><term>Drug Discovery</term><term>Host-Pathogen Interactions (drug effects)</term><term>Models, Chemical</term><term>Molecular Structure</term><term>Plant Leaves (virology)</term><term>Ribavirin (chemistry)</term><term>Ribavirin (pharmacology)</term><term>Structure-Activity Relationship</term><term>Tobacco (virology)</term><term>Tobacco Mosaic Virus (drug effects)</term><term>Tobacco Mosaic Virus (physiology)</term><term>Vanillic Acid (chemistry)</term><term>Vanillic Acid (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide vanillique ()</term><term>Acide vanillique (pharmacologie)</term><term>Acides caféiques ()</term><term>Acides caféiques (pharmacologie)</term><term>Acides coumariques ()</term><term>Acides coumariques (pharmacologie)</term><term>Acrylates ()</term><term>Acrylates (pharmacologie)</term><term>Antiviraux ()</term><term>Antiviraux (pharmacologie)</term><term>Cinnamates ()</term><term>Cinnamates (pharmacologie)</term><term>Découverte de médicament</term><term>Feuilles de plante (virologie)</term><term>Interactions hôte-pathogène ()</term><term>Modèles chimiques</term><term>Relation structure-activité</term><term>Ribavirine ()</term><term>Ribavirine (pharmacologie)</term><term>Structure moléculaire</term><term>Tabac (virologie)</term><term>Virus de la mosaïque du tabac ()</term><term>Virus de la mosaïque du tabac (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acrylates</term><term>Antiviral Agents</term><term>Caffeic Acids</term><term>Cinnamates</term><term>Coumaric Acids</term><term>Ribavirin</term><term>Vanillic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acrylates</term><term>Antiviral Agents</term><term>Caffeic Acids</term><term>Cinnamates</term><term>Coumaric Acids</term><term>Ribavirin</term><term>Vanillic Acid</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Host-Pathogen Interactions</term><term>Tobacco Mosaic Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide vanillique</term><term>Acides caféiques</term><term>Acides coumariques</term><term>Acrylates</term><term>Antiviraux</term><term>Cinnamates</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la mosaïque du tabac</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Tobacco Mosaic Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Feuilles de plante</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Plant Leaves</term><term>Tobacco</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Discovery</term><term>Models, Chemical</term><term>Molecular Structure</term><term>Structure-Activity Relationship</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide vanillique</term><term>Acides caféiques</term><term>Acides coumariques</term><term>Acrylates</term><term>Antiviraux</term><term>Cinnamates</term><term>Découverte de médicament</term><term>Interactions hôte-pathogène</term><term>Modèles chimiques</term><term>Relation structure-activité</term><term>Ribavirine</term><term>Structure moléculaire</term><term>Virus de la mosaïque du tabac</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A series of trans-3-aryl acrylic acids 1-27 and their derivatives 28-34 were prepared and evaluated for their antiviral activity against tobacco mosaic virus (TMV) for the first time. The bioassay results showed that most of these compounds exhibited good antiviral activity against TMV, of which compounds 1, 5, 6, 20, 27 and 34 exhibited significantly higher activity against TMV than commercial Ribavirin both in vitro and in vivo. Furthermore, these compounds have more simple structure than commercial Ribavirin, and can be synthesized more efficiently. These new findings demonstrate that trans-3-aryl acrylic acids and their derivatives represent a new template for antiviral studies and could be considered for novel therapy against plant virus infection.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Tianjin</li></settlement></list><tree><noCountry><name sortKey="Hu, Yanna" sort="Hu, Yanna" uniqKey="Hu Y" first="Yanna" last="Hu">Yanna Hu</name><name sortKey="Meng, Chuisong" sort="Meng, Chuisong" uniqKey="Meng C" first="Chuisong" last="Meng">Chuisong Meng</name><name sortKey="Wang, Kailiang" sort="Wang, Kailiang" uniqKey="Wang K" first="Kailiang" last="Wang">Kailiang Wang</name><name sortKey="Wang, Lizhong" sort="Wang, Lizhong" uniqKey="Wang L" first="Lizhong" last="Wang">Lizhong Wang</name><name sortKey="Wang, Qingmin" sort="Wang, Qingmin" uniqKey="Wang Q" first="Qingmin" last="Wang">Qingmin Wang</name><name sortKey="Wang, Ziwen" sort="Wang, Ziwen" uniqKey="Wang Z" first="Ziwen" last="Wang">Ziwen Wang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Meng" sort="Wu, Meng" uniqKey="Wu M" first="Meng" last="Wu">Meng Wu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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